Genetics of Obesity

Recent studies have verified and identified variants in several genes might contribute to body fat distribution and eventually weight gain. Occurance of Inheritable forms of obesity is evidence that fatness is caused by genetic mutations; seventy eight cases worldwide are attributed to mutations of seven distinct genes. Candidate gene and genome-wide association examines have led to the discovery of nine locus concerned in Mendelian forms of obesity and 58 locus put-up to polygenic obesity. These locus justify a small fraction of the heritability for obesity and many genes remain to be discovered.

•    Prader–Willi syndrome
•    Bardet–Biedl syndrome
•    Cohen syndrome
•    MOMO syndrome
•    Alstrom syndrome
•    Carpenter syndrome
•    Rubinstein-Taybi syndrome

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